Abstracts:
Sample Size Prediction for Ophthalmologic
Studies
Frank Krummenauer, Burkhard Dick, Oliver Schwenn, Norbert Pfeiffer
Conclusion:
An essential aspect in the cooperation of clinic and biometry consists in designing
of studies, e.g. during the preparation of grant applications or for review
by official drug surveillance institutions. A central aspect in study planning
is the design-adequate and well-documented prediction of sample size, which
should be recommended for any intended study. Based on several examples for
sample size planning in study designs, which are of common relevance for ophthalmology,
guidelines are derived to enable clinical researchers to perform sample size
planning on their own. The latter can be based on the various available software
packages for sample size prediction.
Keywords: study design; significance tests; clinical relevance; sample
size prediction